姓名：赵红业
职称：教授
学科：分子肿瘤学
导师类别：博导
电子邮箱：hyzhao2000@126.com
教育经历
1992/9-1996/7 公司 农学学士
1996/9-1999/7 华南农业大学 农学硕士
2002/4-2004/3 日本鹿儿岛大学农学研究科 农学硕士
2004/3-2008/6 日本鹿儿岛大学医齿学综合研究科 医学博士
工作经历
2008/11-2009/3 日本德岛文理大学健康科学研究所 客员研究员
2009/10-2010/8 公司生物多样性国家研究中心 讲师
2010/8-2021/12 公司生物多样性国家研究中心 教授
2022/1-至今 全球十大赌船网址 教授
所授课程
1. 实验动物学
2. 细胞分子生物学
3. 动物福利概论
4. 科研诚信与学术道德教育
研究领域与方向
1、利用基因编辑与体细胞克隆技术创建多种人类小型猪疾病模型，为加快疾病致病机制的解析和诊疗提供了重要的研究素材。
2、利用基因编辑与体细胞克隆技术创建用于异种器官移植的供体猪, 为异种器官移植研究及异种免疫排斥相关研究奠定了重要基础。
3、植物提取物与老药新用、老药联用抗癌的机制，为抗癌药研究提供理论依据。
科研与教学
科研项目
1. 基因编辑疾病模型猪创制项目，江西农业大学，2022/01-2023/12，200万，在研，主持
2. 猪血人源化基因编辑克隆猪的研究，创观（苏州）生物科技有限公司，2021/12-2022/12，35万，在研，主持
3. 猪PAH基因定点修饰成纤维细胞系的构建研发合作协议，浙江大学滨江研究院 2021/9 -2022/8，9.8万，在研，主持
4. 靶向猪的基因编辑体系技术研发合作协议，浙江大学滨江研究院，2021/8-2022/8，9.0万，在研，主持
5. 红细胞基因编辑克隆猪研究开发项目 创观生物公司 2021/8-2022/8，35.0万，在研，主持
6. 基因编辑克隆猪合作协议，杭州启函生物科技有限公司合作项目，2021/01-,131.8万，在研，主持
7. 地方猪遗传材料采集制作，农业农村部种业管理司项目，2019/10-2020/3，20万,在研，主持
8. 异种器官移植多基因修饰克隆猪的构建，杭州启函生物公司横向项目，2018/3-2019/3，200万，在研，主持
9. 自噬在紫杉醇抑制乳腺癌中的作用及其机制研究，国家自然科学基金面上项目，81872452，2019/1-2022/12，57万，在研，主持
10. 美国eGenesis公司合作“异种器官移植克隆猪的生产及功能检测”项目子课题，美国eGenesis，2016/10-2017/12，263万，在研，主持
11. 优良绵羊快速扩繁关键技术集成与示范，内蒙古临河市人民政府，内蒙古河套农牧业研究院，2017530117，2017/3-2020/2，52万，在研，主持
12. 昭通大黑山羊的品种提纯及快速扩繁，昭通市彝良县人民政府，2016/7-2020/6，50万，在研，主持
13. 低浓度紫杉醇诱导KM12C细胞中血管新生抑制因子凝血酶敏感蛋白-1表达的分子机制，国家自然科学基金地区项目，81160282，2012/1-2015/12，57万，已结题，主持
14. 普洱茶活性成分对不同肿瘤细胞系P53表达水平的影响，省政府普洱茶科学行动计划，普洱茶研究院，2011/4-2012/4，100万，已结题，主持
15. 普洱茶调节人体脂代谢的作用机制和产品开发，云南省高院特色研究院， 2013/8-2014/12，100万，已结题，主持
16. 普洱茶水提物诱导肿瘤细胞凋亡及分子机理的研究，省政府普洱茶科学行动计划，普洱茶研究院，2013/3-2014/12，50万，已结题，主持
参与项目共6项:
18. 猪-非人灵长类异种器官移植关键技术的创新与应用，云南省科技厅，2021-2023，1250万，在研，参与
19. 云南省科技创新人才计划“公司动物基因编辑和体细胞克隆技术省创新团队”，2017/8-2020/8，100万，在研，参与
20. 云南省教育厅科技人才计划“云南省高校动物基因编辑和体细胞克隆技术科技创新团队”，2017/1-2019/12，60万，在研，参与
21. 云南省对外科技合作计划“巴基斯坦肉羊扩繁技术集成应用与推广（2016IA024）”，2016/8-2019/7，100万，在研，参与
22. 抗免疫排斥转基因猪的构建及异种移植功能性研究，云南省基础研究重大专项，2014FC006，2014/10-2017/9，100万，在研，参与
23. “云南省高端科技人才引进计划“基因修饰版纳微型猪动物模型的建立”（2011HA011）”，云南省科技厅，2012/1-2014/12，200万，已结题，参与
24. 版纳微型猪近交系体细胞核移植胚胎早期死亡相关基因的筛选，国家自然科学基金项目，31060308，27万，2011/1-2013/12，已结题，参与
学术荣誉与奖励
赵红业（2/8），云南省技术发明一等奖，云南省人民政府，科学技术奖，一等奖，2021年，（魏红江，赵红业，卿玉波，王文，陈翔，成文敏，李鸿辉，贾宝瑜，王配）。
代表性成果
代表性文章
[1] Kaixiang Xu#, Wanyun Zhu#, Anyong Xu#, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei*, Hong-Ye Zhao*. Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells. Molecular Medicine Reports. 2021, 1. 25(2):72. doi: 10.3892/mmr.2022.12588.
[2] Honghui Li#, Wenmin Cheng#, Bowei Chen#, Shaoxia Pu, Ninglin Fan, Xiaolin Zhang, Deling Jiao, Dejia Shi, Jianxiong Guo, Zhuo Li, Yubo Qing, Baoyu Jia, Hong-Ye Zhao*, Hong-Jiang Wei*. Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing. Life (Basel). 2021, 11(12):1417. DOI: 10.3390/life11121417.
[3] Yubo Qing#, Muhammad Ameen Jamal#, Dejia Shi#, Sumei Zhao, Kaixiang Xu, Deling Jiao, Heng Zhao, Honghui Li, Baoyu Jia, Haizhen Wang, Hong-Ye Zhao*, Hong-Jiang Wei*. Delayed body development with reduced triglycerides levels in leptin transgenic pigs. Transgenic Research. 2021, DOI: 10.1007/s11248-021-00288-1.
[4] Deling Jiao#, Wenmin Cheng#, Xiaolin Zhang#, Yifan Zhang#, Jianxiong Guo, Zhuo Li, Dejia Shi, Zhe Xiong, Yubo Qing, Muhammad Ameen Jamal, Kaixiang Xu, Hong-Ye Zhao*, Hong-Jiang Wei*. Improving porcine SCNT efficiency by selecting donor cells size. Cell Cycle. 2021, 20(21):2264-2277. DOI: 10.1080/15384101.2021.1980983.
[5] Luhan Yang, George Church, Hong-Ye Zhao, Lusheng Huang, Yangbin Gao, Hong-Jiang Wei, Geoffrey Yang. Porcine germline genome engineering. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(22): e2004836117. DOI: 10.1073/pnas.2004836117. (IF=11.201)
[6] 熊喆，邹迪，施德佳，杨鑫娇，卿玉波，魏红江，赵红业。饥饿诱导 p53 缺失猪成纤维细胞自噬促进凋亡. 公司学报. 2021，36(4)：590−597. DOI: 10.12101/j.issn.1004-390X(n).202102028.
[7] 杨鑫娇，邹迪，熊喆，张海珠，夏从龙，赵红业。自噬诱导、抑制的人三阴性乳腺癌细胞系MDA-MB-231 中ATG2A和ATG9A表达观察. 山东医药. 2021, 61(21): 13-17.
[8] Yanan Yue#, Weihong Xu#, Yinan Kan#, Hong-Ye Zhao#, Yixuan Zhou, Xiaobin Song, Jiajia Wu, Juan Xiong, Dharmendra Goswami, Meng Yang, Lydia Lamriben, Mengyuan Xu, Qi Zhang, Yu Luo, Jianxiong Guo, Shengyi Mao, Deling Jiao, Tien Dat Nguyen, Zhuo Li, Jacob V. Layer, Mailin Li, Violette Paragas, Michele E. Youd, Zhongquan Sun, Yuan Ding, Weilin Wang, Hongwei Dou, Lingling Song, Xueqiong Wang, Lei Le, Xin Fang, Haydy George, Ranjith Anand, Shi Yun Wang, William F. Westlin, Marc Güell, James Markmann, Wenning Qin, Yangbin Gao, Hong-Jiang Wei*, George M. Church*, Luhan Yang*. Extensive germline genome engineering in pigs. Nature Biomedical Engineering. 2020, 5(2):134-143 DOI: 10.1038/s41551-020-00613-9. (IF=18.952)
[9] Heng Zhao, Yuying Li, Thanapa Wiriyahdamrong, Zaimei Yuan, Yubo Qing, Honghui Li, Kaixiang Xu, Jianxiong Guo, Baoyu Jia, Xuezeng Zhang, Wenmin Cheng, Yanhua Su, Weihu Long, Jing Wang, Di Zou, Keji Kinoshita, Hong-Ye Zhao*, Hong-Jiang Wei*. Improved production of GTKO/hCD55/hCD59 triple-genemodified Diannan miniature pigs for xenotransplantation by recloning. Transgenic Research. 2020, 29(3):369-379. (IF=1.856)
[10] Jimin Fei#, Anyong Xu#, Wen Zeng, Yukun Liu, DelingJiao, Wanyun Zhu, Kaixiang Xu, Honghui Li, Hong-Jiang Wei*, Hong-Ye Zhao*. The Molecular Basis for P53 Inhibition of Autophagy in Porcine Fibroblast Cells. Translational Cancer Research. 2019, 8(3): 876-886. (IF=1.2)
[11] Deling Jiao#, Zhen Yang#, Lulu Wang#, Binyue Hu, Jing Wang, Anyong Xu, Wenmin Cheng, Baoyu Jia, Yubo Qing, Hong-Ye Zhao*, Hong-Jiang Wei*. Endogenous leptin promotes autophagy in EBSS-induced PFCs. Animal Cells and Systems. 2019, 23(5): 318-325. (IF=0.549)
[12] Fengjuan Liu, Jinji Liu, Zaimei Yuan, Yubo Qing, Honghui Li, Kaixiang Xu, Wanyun Zhu, Heng Zhao, Baoyu Jia, Weirong Pan, Jianxiong Guo, Xuezeng Zhang, Wenmin Cheng, Wei Wang*, Hong-Ye Zhao*, Hong-Jiang Wei*. Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT. Molecular Biotechnology. 2018, 60(8):550-562. (IF= 1.815)
[13] Honghao Yu#, Weihu Long#, Xuezeng Zhang#, Kaixiang Xu, Jiangxiong Guo, Heng Zhao, Honghui Li, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Xingxu Huang* and Hong-Jiang Wei*. Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. Journal of translational medicine. 2018, 16:41. (IF=4.197)
[14] Wenjing Li#, Wangyun Zhu#, Chaoxiang Lv, Hao Qu, Kaixiang Xu, Honghui Li, Haifeng Li, Yiming Du, Guangming Liu, Yunyue Wang*, Hong-Jiang Wei*, Hong-Ye Zhao*. Low-dose paclitaxel downregulates MYC proto-oncogene bHLH transcription factor expression in colorectal carcinoma cells. Oncology Letters. 2018,15:1881-1887. (IF=1.664)
[15] Yongfeng Shen#, Kaixiang Xu#, Zaimei Yuan, Jiangxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*， Wei Hong-Jiang*. Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer. Journal of translational medicine. 2017, 15:224-234. (IF=4.197)
[16] Chaoxiang Lv#, Hao Qu#, Wanyun Zhu, Kaixiang Xu, Anyong Xu, Baoyu Jia, Yubo Qing, Honghui Li, Hong-Jiang Wei*, Hong-Ye Zhao*. Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells. Frontiers in Pharmacology. 2017, 8:244. (IF=4.481)
[17] Jing Xie, Haishuang Yu, Shuang Song, Chongye Fang, Xuanjun Wang, Zhongbin Bai, Xiao Ma, Shumei Hao, Hong-Ye Zhao*, Jun Sheng*. Pu-erh Tea Water Extract Mediates Cell Cycle Arrest and Apoptosis in MDA-MB-231 Human Breast Cancer Cells. Frontiers in Pharmacology. 2017, 8(E547):190. (IF=4.481)
[18] Wanyun Zhu#, Hao Qu#, Kaixiang Xu, Baoyu Jia, Guangming Liu, Hong-Jiang Wei*, Hong-Ye Zhao*. Differences in the starvation-induced autophagy response in MDA-MB-231 and MCF-7 breast cancer cells. Animal Cells & Systems. 2017, 21(3):1-9. (IF= 0.544)
[19] Wenmin Cheng#, Heng Zhao#, Honghao Yu, Jige Xin, Jia Wang, Luyao Zeng, Zaimei Yuan, Yubo Qing, Honghui Li, Baoyu Jia, Cejun Yang, Youfeng Shen, Lu Zhao, Weirong Pan, Hong-Ye Zhao*, Wei Wang*, Hong-Jiang Wei*. Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer. Reproductive biology and Endocrinology. 2016, 14: 77. (IF= 2.147)
[20] Honghui Li, Gui Wang, Zhiqiang Hao, Guozhong Zhang, Yubo Qing, Shuanghui Liu, Lili Qing, Weirong Pan, Lei Chen, Guichun Liu, Ruoping Zhao, Baoyu Jia, Luyao Zeng, Jianxiong Guo, Lixiao Zhao, Heng Zhao, Chaoxiang Lv, Kaixiang Xu, Wenmin Cheng, Hushan Li, Hong-Ye Zhao*, Wen Wang*, Hong-Jiang Wei*. Generation of biallelic knock-out sheep via gene-editing and somatic cell nuclear transfer. Scientific Reports. 2016, 6: 33675. DOI: 10.1038/srep33675. (IF=5.578)
[21] Weirong Pan, Guozhong Zhang, Yubo Qing, Honghui Li, Wenmin Cheng, Xin Wang, Xiaobing Li, Yingchao Liu, Yuanyuan Qi, Jia Wang, Liangxue Lai, Hong-Ye Zhao*, Hong-jiang Wei*. Evaluation of cloning efficiency based on the production of cloned Diannan miniature pigs. Journal of microbiology and biotechnology. 2015, 4(4):1-7.
[22] Yubo Qing, Wenmin Cheng, Yingchao Liu, Xiaobing Li, Weirong Pan, Honghui Li, Si Li, Baoyu Jia, Liangxue Lai, Hong-Ye Zhao*, Hong-Jiang Wei*. Development before and after cryopreservation of porcine parthenogenetic embryos derived from early-delipated oocytes. Journal of microbiology and biotechnology. 2015, 4(4):47-54.
[23] Hong-Ye Zhao*, Hong-Jiang Wei, Xin Wang. The reciprocal interaction of small molecule protein kinase inhibitors and ATP-Binding cassette transporters in targeted cancer therapy. Journal of cancer research updates. 2013, 2: 68-86.
[24] Hong-Ye Zhao, Akio Ooyama, Masatatsu Yamamoto, Ryuji Ikeda, Misako Haraguchi, Sho Tabata, Tatsuhiko Furukawa, Xiao-Fang Che, Zhang S, Toshinori Oka, Masakazu Fukushima, Masayuki Nakagawa, Mayumi Ono, Michihiko Kuwano, Shin-ichi Akiyama. Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU. Cancer research. 2008, 68(17): 7035-7041. (IF=9.329)
[25] Hong-Ye Zhao, Akio Ooyama, Masatatsu Yamamoto, Ryuji Ikeda, Misako Haraguchi, Sho Tabata, Tatsuhiko Furukawa, Xiao-Fang Che, Ken-ichi Iwashita, Toshinori Oka, Masakazu Fukushima, Masayuki Nakagawa, Mayumi Ono, Michihiko Kuwano, Shin-ichi Akiyama. Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells. Cancer letters. 2008, 270(1):156-163. (IF=5.621)
[26] Junchen Chen , Weiqi Zeng , Weirong Pan , Cong Peng, Jianglin Zhang, Juan Su, Weihu Long, Heng Zhao, Xiaoxia Zuo, Xiaoyun Xie, Jing Wu, Ling Nie, Hong-Ye Zhao*, Hong-Jiang Wei*, Xiang Chen*. Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs. PLoS Biol. 2018, 16(8): e2005354. (IF= 9.163)
[27] Shaoxuan Zhang,Yarong Li,Tatsuhiko Furugawa, Homare Takahashi, Xiaofang Che, Hong-Ye Zhao, Sinichi Akiyama. Gene expression analysis in gemcitabine resistant cells derived from human pancreatic cancer cell. Journal of Convergence Information Technology. 2018, 6(1): 460-466.
[28] Dong Niu *, Hong-Jiang Wei *, Lin Lin*, Haydy George *, Tao Wang *, I-Hsiu Lee *, Hong-Ye Zhao, Yong Wang, Yinan Kan, Ellen Shrock, Emal Lesha, Gang Wang, Yonglun Luo, Yubo Qing, Deling, Jiao, Heng Zhao, Xiaoyang Zhou, Shouqi Wang, Hong Wei, Marc Guell, George M. Church and Luhan Yang. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science. 2017, 357:1303-1307. (IF= 41.058)
[29] Honghao Yu#, Heng Zhao#, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Xingxu Huang*, Hong-Jiang Wei*. Porcine zygote injection with Cas9/sgRNA Results in DMD-modified pig with muscle dystrophy. International journal of molecular sciences. 2016, 17: 1668. (IF=3.257)
[30] Hongjiang Wei, Yubo Qing, Weirong Pan, Hong-Ye Zhao, Honghui Li, Wenmin Cheng, Lu Zhao, Chengsheng Xu, Hong Li, Si Li, Lei Ye, Taiyun Wei, Xiaobing Li, Guowen Fu, Wengui Li, Jige Xin, Yangzhi Zeng. Comparison of the Efficiency of Banna Miniature Inbred Pig Somatic Cell Nuclear Transfer among Different Donor Cells. Plos one. 2013, 8(2): e57728. (IF= 2.766)
[31] Kenichi Yoshida, Tatsuhiko Furukawa, Xiao-Fang Che, Tatsuya Yamaguchi, Mina Ushiyama, Akihiko Miyawaki, Yasuo Takeda, Masatatsu Yamamoto, Hong-Ye Zhao, Yoshihiko Shibayama, Katsushi Yamada ,Shin-ichi Akiyama. Hyperosmotic Stress Up-regulates the Expression of Major Vault Protein in SW620 Human Colon Cancer Cells. Experimental Cell Research. 2008, 314(16) : 3017-26. (IF= 3.309)
[32] Ryuji Ikeda, Yusuke Tajitsu, Ken-Ichi Iwashita, Xiao-Fang Che, Kenichi Yoshida, Mina Ushiyama, Tatsuhiko Furukawa, Masaharu Komatsu, Tatsuya Yamaguchi, Yoshihiko Shibayama, Masatatsu Yamamoto, Hong-Ye Zhao, Junko Arima, Yasuo Takeda, Katsushi Yamada, Shin-Ichi Akiyama. Thymidine Phosphorylase Inhibits the Expression of Proapoptic Protein BNIP3. Biochemical and Biophysical Research Communications. 2008, 370(2):220-4. (IF= 2.559)
[33] Akio Ooyama, Toshinori Oka, Hong-Ye Zhao, Masatatsu Yamamoto, Shin-ichi Akiyama, Masakazu Fukushima. Anti-angiogenic effect of 5-fluorouracil-based drugs against human colon cancer xenografts. Cancer letter. 2008, 267(1): 26-36. (IF=5.621)
[34] Hei-Cheul Jeung, Xiao-Fang Che, Misako Haraguchi, Hong-Ye Zhao, Tatsuhiko Furukawa, Takenari Gotanda, Chun-Lei Zheng, Kengo Tsuneyoshi, Tomoyuki Sumizawa, Jae Kyung Roh, Shin-Ichi Akiyama, Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase. FEBS Letters. 2006, 580(5):1294-302. (IF= 2.999)
[35] Kengo Tsuneyoshi, Misako Haraguchi, Hong-Ye Zhao, Takenari Gotanda, Tokushi Tachiwada, Tomoyuki Sumizawa, Tatsuhiko Furukawa, Masanori Baba, Shin-Ichi Akiyama, Masayuki Nakagawa. Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity. Cancer Letter. 2006, 244(2):239-46. (IF=5.621)
[36] Taishi Yanohara, Shigehisa Okamoto, Hong-Ye Zhao, Yasushi Nakamura, Tomoaki Matsuo. Preparation of proteins from different organs of Japanese morning glory by an in vivo electro-elution procedure. Phytochemical Analysis. 2005, 16(6):397-404. (IF= 2.337)
[37] Taishi Yanohara, Zhao Hongye, Tomoaki Matsuo. Fluctuations in extra-cellular proteins collected from epicotyls of Japanese morning glory treated by high temperature and dehydration stresses. Journal of Food Agriculture & Environment. 2005, 3:231-236.
专利
[1] 赵红业，魏红江，申友锋，李鸿辉，赵恒，角德灵. 通过敲除P53基因获得淋巴瘤小型猪疾病模型的方法，2019年3月15日授权，中国，ZL 201510717721.9；
[2] 魏红江，李鸿辉，赵红业，卿玉波，角德灵. 一种构建过量表达Leptin基因的克隆猪的方法，2019年3月5日授权，中国，ZL 201510715885.8；
[3] 魏红江，王文，卿玉波，赵红业，角德灵.一种利用体细胞克隆技术培育地方优良家畜品种的方法，2019年7月12日授权，中国，ZL201611224097.X；
[4] 魏红江，赵红业，赵鲁. 一种利用连续克隆技术生产孤雌生殖克隆猪的方法，2017年7月25日授权，中国，ZL 201310295393.9；
[5] 魏红江，角德灵，赵红业，王跃宁，芮绍辉，何瑞清，钟文庆，余波. 一种装配式可移动标准化饲养羊舍，2017年7月28日授权，中国，ZL 201610665810.8；
[6] 魏红江，赵红业，许烨，潘伟荣，陈关雄. 城市餐饮泔水系统分离方法，2010，中国， ZL 201010140833.X；
[7] 魏红江，赵红业，潘伟荣，陈关雄. 餐饮废水除油器，2010，中国，ZL 201010151915.X。
授权实用新型专利：
[8] 魏红江，赵红业，潘伟荣，陈关雄. 餐饮废水除油器，2010，中国，ZL 201010151915.X；
[9] 魏红江，角德灵，赵红业，王跃宁，芮绍辉，何瑞清，钟文庆，余波. 一种装配式可移动标准化饲养羊舍，2016，中国，ZL201620878400.7
写给学生的话：
简单的事重复做，你就是专家，重复的事你用心做，你就是赢家。
